Mle equation for nonmem1/7/2023 ![]() Increased efficiency of dynamic memory allocation to handle very large problems, eliminating the need to recompile the NONMEM® program for unusually large problemsĪdditional features, some new to NONMEM 7. Parallel computing of a single problem over multiple cores or computers, for estimation, covariance assessment, simulation, nonparametric analysis and posthoc parameter and weighted residual diagnostic evaluation, significantly reducing completion timeģ. Markov-Chain Monte Carlo Bayesian Analysis (BAYES, NUTS)Ģ.described in Equation 10.6 are represented by the following equations. ![]()
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